Manganic encephalopathy due to “ephedrone” abuse
Identifieur interne : 002D52 ( Main/Exploration ); précédent : 002D51; suivant : 002D53Manganic encephalopathy due to “ephedrone” abuse
Auteurs : Yanush Sanotsky [Ukraine] ; Roman Lesyk [Ukraine] ; Lyudmyla Fedoryshyn [Ukraine] ; Iryna Komnatska [Ukraine] ; Yuriy Matviyenko [Ukraine] ; Stanley Fahn [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-07-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Manganèse, Toxicomanie.
English descriptors
- KwdEn :
- Abuse, Adult, Basal Ganglia (pathology), Brain Diseases (etiology), Brain Diseases (pathology), Drug addiction, Encephalopathy, Humans, Magnetic Resonance Imaging, Male, Manganese, Manganese Poisoning (complications), Middle Aged, Nervous system diseases, Parkinsonism, Poisoning, Propiophenones (adverse effects), Retrospective Studies, Substance-Related Disorders (complications), Substance-Related Disorders (etiology), drug‐addiction, ephedronic encephalopathy, manganese poisoning, manganic encephalopathy, parkinsonism.
- MESH :
- chemical , adverse effects : Propiophenones.
- complications : Manganese Poisoning, Substance-Related Disorders.
- etiology : Brain Diseases, Substance-Related Disorders.
- pathology : Basal Ganglia, Brain Diseases.
- Adult, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies.
Abstract
We describe the clinical and neuroimaging features of 6 drug‐abuse patients with self‐inflicted manganese poisoning. The patients injected a home‐brewed mixture called “ephedrone” (slang term) that contained manganese to produce an amphetamine‐like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common‐cold–remedy compound using permanganate as the catalyst. Manganese was a by‐product in the ephedrone mixture. After months of self‐injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic‐hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1‐weighted signals in the basal ganglia, typical of manganese accumulation. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21378
Affiliations:
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Le document en format XML
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first="Iryna" last="Komnatska">Iryna Komnatska</name><affiliation wicri:level="1"><country xml:lang="fr">Ukraine</country><wicri:regionArea>Department of MRI, Central Hospital of the Lviv Regional Railway, Lviv</wicri:regionArea><wicri:noRegion>Lviv</wicri:noRegion></affiliation></author><author><name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name><affiliation wicri:level="1"><country xml:lang="fr">Ukraine</country><wicri:regionArea>Department of Neurology, Danylo Halytsky Lviv National Medical University, Lviv</wicri:regionArea><wicri:noRegion>Lviv</wicri:noRegion></affiliation></author><author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Columbia University Medical Center, New York, New 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-07-15">2007-07-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1337">1337</biblScope><biblScope unit="page" to="1343">1343</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F413AA9196661F325739EF0F1A235A496AFFEBA2</idno><idno type="DOI">10.1002/mds.21378</idno><idno type="ArticleID">MDS21378</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abuse</term><term>Adult</term><term>Basal Ganglia (pathology)</term><term>Brain Diseases (etiology)</term><term>Brain Diseases (pathology)</term><term>Drug addiction</term><term>Encephalopathy</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Manganese</term><term>Manganese Poisoning (complications)</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinsonism</term><term>Poisoning</term><term>Propiophenones (adverse effects)</term><term>Retrospective Studies</term><term>Substance-Related Disorders (complications)</term><term>Substance-Related Disorders (etiology)</term><term>drug‐addiction</term><term>ephedronic encephalopathy</term><term>manganese poisoning</term><term>manganic encephalopathy</term><term>parkinsonism</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Propiophenones</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Manganese Poisoning</term><term>Substance-Related Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Brain Diseases</term><term>Substance-Related Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia</term><term>Brain Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Abus</term><term>Encéphalopathie</term><term>Intoxication</term><term>Manganèse</term><term>Parkinsonisme</term><term>Système nerveux pathologie</term><term>Toxicomanie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Manganèse</term><term>Toxicomanie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We describe the clinical and neuroimaging features of 6 drug‐abuse patients with self‐inflicted manganese poisoning. The patients injected a home‐brewed mixture called “ephedrone” (slang term) that contained manganese to produce an amphetamine‐like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common‐cold–remedy compound using permanganate as the catalyst. Manganese was a by‐product in the ephedrone mixture. After months of self‐injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic‐hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1‐weighted signals in the basal ganglia, typical of manganese accumulation. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Ukraine</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="Ukraine"><noRegion><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name></noRegion><name sortKey="Fedoryshyn, Lyudmyla" sort="Fedoryshyn, Lyudmyla" uniqKey="Fedoryshyn L" first="Lyudmyla" last="Fedoryshyn">Lyudmyla Fedoryshyn</name><name sortKey="Komnatska, Iryna" sort="Komnatska, Iryna" uniqKey="Komnatska I" first="Iryna" last="Komnatska">Iryna Komnatska</name><name sortKey="Lesyk, Roman" sort="Lesyk, Roman" uniqKey="Lesyk R" first="Roman" last="Lesyk">Roman Lesyk</name><name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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